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Bas-Congo virus - emerging disease
Dissonant Cog
Registered User
User ID: 123967
09-28-2012 09:33 AM

Posts: 1,753



Post: #1
Bas-Congo virus - emerging disease
Bas-Congo virus after the province where it was found just west of Kinshasa, the teeming capital of the Democratic Republic of Congo. The discovery was announced today in the journal PLoS Pathogens. So far only three people in the remote village of Mangala are known to have contracted Bas-Congo hemorrhagic fever, two of whom died. One was a health care worker who cared for the other two villagers, which means it can apparently be transmitted from person to person, although no one knows how easily. But the small number of known cases is actually one of the important things about this finding. It signifies that scientists may have found an emerging disease very soon after it made its jump from whatever species it came from into humans. We'll come back to its most likely origins a little later. The reason for thinking Bas-Congo only recently began infecting humans is that researchers have run blood tests on people throughout the DRC and found no evidence of antibodies that would indicate any of them has been exposed to the new virus. "It doesn't appear to be widespread throughout the Congo," study co-author Charles Chiu of the University of California San Francisco told Shots. He says the team is planning to do more blood tests on people in the DRC and neighboring countries, such as Congo-Brazzaville right next to Bas-Congo province. "I would say we caught it fairly quickly," said another study author, Joseph Fair, in a telephone interview from the other side of the DRC, where he's helping to track down the origin of an ongoing outbreak of Ebola hemorrhagic fever that has so far afflicted 51 people and killed 20.

"This wasn't HIV, where we're 15 years into a pandemic before we actually find that we have a pandemic," says Fair, who's with a group called Metabiota that contracts with governments and health agencies to track disease outbreaks. The three known cases of Bas-Congo fever actually occurred three years ago. But tissue samples from the victims languished in a laboratory freezer in Kinshasa until an astute doctor called the cases to Fair's attention. That time lag, along with the inability to keep some tissue samples from thawing out, has hampered the researchers' ability to track the virus through other possible cases in Mangala village. There are some other striking things about the new virus. It doesn't belong to any of the four families of previously known hemorrhagic viruses – Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae. These families harbor such notorious bugs as Ebola, Marburg, Lassa fever, Crimean-Congo hemorrhagic fever, dengue fever and Rift Valley Fever. Instead, Bas-Congo belongs to the Rhabdovirus family, which has never been known to include human hemorrhagic fever viruses, although it does contain one that affects fish. "That in itself is astonishing," Chiu says, "but even within the rhabdovirus family, it's very divergent." That is, it doesn't resemble any other rhabdovirus.

http://hisz.rsoe.hu/alertmap/site/?pagei...-36700-COG
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LoP Guest
lop guest
User ID: 79813
09-28-2012 09:57 AM

 



Post: #2
RE: Bas-Congo virus - emerging disease
"very divergent". Not resembling its kind.


Hmm. hmmm. Just how divergent are we talking? There must be some resemblance. Not sure what to make of this op. Sounds sorta uh well engineered?
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Dissonant Cog
Registered User
User ID: 123967
09-28-2012 11:15 AM

Posts: 1,753



Post: #3
RE: Bas-Congo virus - emerging disease
Yes, as usual this report raises more questions than answers for me :

The reason for thinking Bas-Congo only recently began infecting humans is that researchers have run blood tests on people throughout the DRC and found no evidence of antibodies that would indicate any of them has been exposed to the new virus.
Interesting - so when did they do this and were they looking for it?

also
a group called Metabiota that contracts with governments and health agencies to track disease outbreaks (hmm). The three known cases of Bas-Congo fever actually occurred three years ago.

Sorry - so is this new or old news?

But tissue samples from the victims languished in a laboratory freezer in Kinshasa until an astute doctor called the cases to Fair's attention.
Not that astute if it took him 3 years

That time lag, along with the inability to keep some tissue samples from thawing out, has hampered the researchers' ability to track the virus through other possible cases in Mangala village.

So are they saying it has been released due to thawing??

http://www.gvfi.org/assets/globalviral-m...leases.pdf Says 'San Francisco, CA –Global Viral Forecasting Initiative, a non-profit organization
and Global Viral Forecasting Inc., a for-profit company, have worked in tandem
since 2009 to conduct in-depth field research and services to better understand
and control the spread of microbial threats.

So about the same time it was put in the freezer.

More research needed I think - Heartflowers
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•REC
14877
User ID: 14877
09-28-2012 12:02 PM

Posts: 27,129



Post: #4
RE: Bas-Congo virus - emerging disease
New virus in Africa looks like rabies, acts like Ebola

A virus that killed two teenagers in Congo in 2009 is a completely new type, related to rabies but causing the bleeding and rapid death that makes Ebola infection so terrifying, scientists reported on Thursday. They’re searching for the source of the virus, which may be transmitted by insects or bats.

The virus infected a 15-year-old boy and a 13-year-old girl in the same village in Congo in 2009

“They expired within three days, It was a very rapid killer.”

A few days later a male nurse who cared for the two teenagers developed the same symptoms and survived.

“We were astounded that this patient had sequences in his blood from a completely unknown and unidentified virus.”

It worries Chiu because its closest relative is spread by biting flies in Australia. “We think that is potentially a valuable clue. This virus may have come from an insect vector,” Chiu says. “What is scary about this virus is if it does happen to be spread by insects, it has the potential to be something like West Nile."

Scream1

More-
http://vitals.nbcnews.com/_news/2012/09/...ebola?lite
(This post was last modified: 09-28-2012 12:03 PM by •REC.) Quote this message in a reply








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